Crises abound for the mentally and physically exhausted web-slinger! After going down to defeat at the hands of Shriek and Carrion last issue, the beleaguered wall-crawler limps back home to rest! However his much-needed rest is denied upon learning that his dear Aunt May has suffered a stroke! In Forest Hills Peter grieves with Mary Jane, but he cannot stay for long as Shriek is still at large. Finally in Astoria in Carrion's mother's house, the amazing one catches up with Shriek! Can the Spectacular Spider-Man silence Shriek once and for all?